Crash between two lorries and a minibus leaves people trapped in vehicles
The motorway has now been closed in both directions between junction 14 at Hungerford and Junction 13 at Chieveley causing travel chaos.
South Central Ambulance Service hasn't confirmed how many people are currently trapped.
It is understood three air ambulances have been scrambled.
A spokesperson said: "We currently have three ambulances, a silver officer, a paramedic team leader, the Thames Valley Air Ambulance and critical care car, as well as our Hazardous Area Response team at the scene."
Thames Valley Police are also at the scene and have urged drivers to take alternative routes.
The eastbound carriageway is expected to be closed until tonight leading to long delays.
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